Tuesday: Harmonization FAILURE !!!

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I have been riding a wave of feeling good, looking good, and hopeful that my medical condition was about to get much better with labs on the table coming today.

I was terribly Disappointed with my doctor visit today.

  • Yes, I have lost some serious weight
  • Yes, I have been on the Keto Diet since the end of March 2016
  • We added Edurant (HIV) medication (once daily dosing)
  • And upped my Trulicity (dosage weekly)

My HIV numbers are stellar. Cd4’s are above 1000, but:

  • My sugar test stick at the clinic was 20.7
  • My resting fast was 20 on paper
  • And my sugar number was 9.5
  • My Triglycerides were high as well (they have been see sawing for ever)

It was obvious today, that the Harmonization Tests of both types of medication have Failed. Either the drugs are conflicting still, the dosage is wrong, or put bluntly, my doctor could not find an “on paper reason” for my numbers to be so, “out of whack” today.

With serious weight loss, and corrective diet, and reworked medication, a change should have appeared on paper, and didn’t.

My doctors had a phone conference as I sat there, when they decided to test me right then and there to check my sugars, by test strip. Which landed at 20.7.

I test at home and my numbers bounce from 10, up to 20 on any given day. Even if I have a restricted diet, and I am not putting bad food into my system and I am eating a restricted diet, the numbers should be working in my favor, but they are not.

Friends have said that I need to keep my head on and wait to see what the Diabetes clinic says at my emergency appointment on Friday morning, and not jump to any conclusions.

I might need insulin corrective medication added, or just rework my insulin regulation  or they are going to change the mix again.

Some people, I have heard, cannot regulate their sugars successfully and need serious medical intervention. It seems I am at that point myself.

Stay tuned …

Thursday Episode 1 – Harmonization

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Years ago, when I was diagnosed with Type 2 diabetes, I started drug regimens very slowly. Over those years, it seemed the drugs were not working as well as expected.

What we did not know then, was that having dual diseases meant that both sets of drugs had to harmonize, so that both regimens worked on their associated problems.

Together.

Last fall, Dr. George changed up my Diabetes medication and added Trulicity to the mix at a low dose. Trulicity is a once a week injection. I began to loose serious weight, for the first time in over twenty years.

In February when I saw him again, the numbers were still too high. I then went to see Dr. Chris, and that day both he and Dr. George were in the same office. They had figured out, for the first time since I got sick, that the drugs were knocking each other out, one for one, thereby negating the effectiveness of the drugs across the board.

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Dr. Chris took away a few drugs, and added new ones, on single dose daily dosing. Dr. George upped my Trulicity to a higher weekly dosage as well, he tweaked my other diabetes medications also.

I had lost ten pounds by the February medical check-up. In March, my friend Joe introduced me to the KETO diet. Which I jumped on furiously.

I have lost a total of thirty pounds so far.

In the words of the Divine Miss M … I Look Good !

Today, I was up at 6 a.m. to make my trek up the hill to the General to drop labs.

Three months of new drugs, one intense diet that has totally changed the way I live, and a lot more healthy living, we will see just how good this harmonization test worked.

If it was successful we will have found a new way to treat dual diagnosis patients with HIV and Type 2 Diabetes.

Let Us Pray …

Thursday: Dueling Dragons …

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It was a pleasantly BALMY day in Montreal today. This week, we saw temps that are darn right Springy … But we are warned that it won’t last, and that March is going to keep us in the cold for another month.

This week saw all kinds of change.

I live with competing dragons in my system. And either one can be in control, but not both at the same time. And one never knows who is in control until I drop labs. This round, my HIV is in good check but my Diabetes is all out of whack.

On Tuesday I went to clinic one for my lab drop session. Both brothers were in attendance, I got to kill two birds with one stone. The drawback is this, depending on who rules the roost, medication has to be adjusted, and you can’t adjust one side without adjusting the other accordingly.

Doctor Chris, over the years, has managed my medications very well. Because I’ve been testing drugs for him for many, many years. And if they work for me, (in our respective medical circle of drug testers), we are the main line to getting drugs approved in Canada on the whole. So what we do is very important for the community at large.

One by one, over the last five years, my twice a day drugs, have been dropped, opting for once a day dosing medication. But the Once a Day dosing takes time, because the new drugs in the pike were taking longer than usual to get to me, (read Us).

This week, new drugs came online finally. But, if you change one side of the equation, then you have to change the other in conjunction. HIV medications and Diabetes medications, don’t always work together. And I don’t know if one or the other is working well, without trial and error dosing.

If the trend drops either way, the HIV drugs come first.

If I don’t live, no other drug is going to make a difference. So Doctor Chris has to make sure that any new drug he gives me now, needs to plays nice with Diabetes drugs. This round, Diabetes lost.

A new Single dose HIV medication came online … EDURANT

Before I could take this pill, Doctor Chris had to make sure it would work with everything else I was taking already. It didn’t. Which meant my Diabetes drugs had to be tweaked.

Doctor George dropped my Janumet, because Metformin cancels out any good the Edurant will do. Which means I am down one Diabetes drug. And that was the end of that appointment.

Wednesday, I saw Doctor George at his clinic and along with his trial nurse, tried to figure out what they needed to do to make up the difference.

Three months ago, I went on Trulicity injections, once a week at a low dose. Now, it seems, that the low dose was not enough, because I am not managing well at all.

While they conferred together, I stepped on the scale and learned that I dropped ten pounds over the last six months. I knew something was up, when I put on a pair of hubby’s skinny jeans and they fit, WELL.

My Diabetes team upped my Trulicity to double the dose, weekly, along with Invokana, I have a bottle of Glyburide hanging in the wings if need be.

When I got home, I sat down with my nutritional map and planned another tweak to my diet, I am working to eliminate sugar intake at all levels. I put the new plan into action, and I have three months to see how all these changes work together.

If this series works, as it is hoped it will, I will manage both dragons better, and that is the plan. I can produce 1200 t-cells with my eyes closed. That is a given. I am over the ten year mark where my viral load is still undetectable.

Diabetes on the other hand is a capricious lady, who does not play well on the playground.

I have to test every other day to check my trends. I don’t have to prick myself every day any more. The Trulicity is a slow release, weekly dosage. Now that dosage is doubled, along with a moderated dietary plan, it should all work.

Now we dose for this observation period. And I hope to see further weight loss, and better numbers overall.

**** **** ****

Tonight’s take away … I would be ok, if everyone would just leave me alone.

How many of us got to this point before we stepped into the rooms.

Our speaker tonight got sober in December of 1994, the same year I got sober the first time, and I was reminded that had I stayed the first time, I would be 23 years sober now.

But that was not meant to be, and as he said to me, I had a hiccup.